abstract：:The plasma kallikrein/kinin system that consists of the proteins factor XII, prekallikrein, and high molecular weight kininogen was first recognized as a surface-activated coagulation system arising when blood or plasma interacts with artificial surfaces. Although surface-activated contact activation occurs in vivo wh...

journal_title：International immunopharmacology

authors： Schmaier AH

更新日期：2008-02-01 00:00:00

abstract：:B1 kinin receptor (B1R) is up-regulated by endotoxins and thus may represent a therapeutic target in sepsis. We investigated the expression and role of B1R and B2R in the acute phase of lipopolysaccharide (LPS)-induced endotoxin shock in C57BL/6 mice (WT) and B1R and B2R knock out mice (B1KO, B2KO). B1R mRNA was enhan...

journal_title：International immunopharmacology

authors： Seguin T,Buleon M,Destrube M,Ranera MT,Couture R,Girolami JP,Tack I

更新日期：2008-02-01 00:00:00

abstract：:With respect to functional aspects, the kallikrein-kinin-system can be divided into a plasma kallikrein-kinin-system and a tissue kallikrein-kinin-system. At least four functional kinin peptides act via two different G-protein-coupled receptors, an inducible B1-receptor and a constitutively expressed B2-receptor. B1R ...

journal_title：International immunopharmacology

authors： Zubakova R,Gille A,Faussner A,Hilgenfeldt U

更新日期：2008-02-01 00:00:00

abstract：:The immunomodulatory effect of metronidazole (MTZ), a nitroimidazole drug used as an antiprotozoal and antibacterial agent, was investigated using Balb/c mice and human peripheral blood lymphocytes. For in vivo studies, mice were divided into six groups, six animals per group, group I received vehicle alone while the ...

journal_title：International immunopharmacology

authors： Fararjeh M,Mohammad MK,Bustanji Y,Alkhatib H,Abdalla S

更新日期：2008-02-01 00:00:00

abstract：:For fish immune defences, cytokines and anti-microbial peptides (lysozyme) in circulating system play important roles. In the present study, the effects of Astragalus polysaccharides (APS) injection on gene expression of interleukin 1beta (IL-1beta), tumor necrosis factoralpha (TNF-alpha) and lysozyme-C in the head ki...

journal_title：International immunopharmacology

authors： Yuan C,Pan X,Gong Y,Xia A,Wu G,Tang J,Han X

更新日期：2008-01-01 00:00:00

abstract：:Cancers of the lung and pleura remain a major cause of cancer deaths, both in men and women, with strong causal relationships between cigarette smoking and asbestos fibres, and deaths from lung cancer and mesothelioma, respectively. The poor survival rates for small cell lung cancer and mesotheliomas argue powerfully ...

journal_title：International immunopharmacology

authors： Motadi LR,Misso NL,Dlamini Z,Bhoola KD

更新日期：2007-12-20 00:00:00

abstract：:Ischemia-reperfusion injury is a common early event in kidney transplantation and contributes to a delay in organ function. Acute tubular necrosis, impaired kidney function and organ leukocyte infiltration are the major findings. The therapeutic potential of stem cells has been the focus of recent research as these ce...

journal_title：International immunopharmacology

authors： da Silva LB,Palma PV,Cury PM,Bueno V

更新日期：2007-12-15 00:00:00

abstract：:IL-6 is involved in inflammation and a therapeutic target. 0.1% of Danish blood donors have nanomolar plasma concentrations of polyclonal, picomolar affinity and in vitro as well as in vivo neutralizing IgG autoantibodies to IL-6 (aAb-IL-6). Such donors are assumed to be severely IL-6 deficient; yet they appear health...

journal_title：International immunopharmacology

authors： Galle P,Jensen L,Andersson C,Cuzzocrea S,Di Paola R,Nicoletti F,Svenson M,Bendtzen K,Thomsen AR,Hansen MB

更新日期：2007-12-15 00:00:00

abstract：:Cytokine-induced killer (CIK) cells are ex vivo expanded T cells with natural killer cell phenotypes and functions. In this study, the anti-tumor activity of CIK cells against hepatocellular carcinoma was evaluated in vitro and in vivo. In the presence of anti-CD3 antibody and IL-2 for 14 days, human peripheral blood ...

journal_title：International immunopharmacology

authors： Kim HM,Lim J,Yoon YD,Ahn JM,Kang JS,Lee K,Park SK,Jeong YJ,Kim JM,Han G,Yang KH,Kim YJ,Kim Y,Han SB

更新日期：2007-12-15 00:00:00

abstract：:The presence of circulating antibodies from primary Sjögren Syndrome (pSS) patients enable to interact with rat cerebral frontal cortex by activating muscarinic acetylcholine receptors (mAChR). ELISA assay for PGE2 generation, nitric oxide synthase (NOS) activity was measured in cerebral frontal cortex slices by produ...

journal_title：International immunopharmacology

authors： Orman B,Sterin-Borda L,De Couto Pita A,Reina S,Borda E

更新日期：2007-12-05 00:00:00

abstract：:The presence of thrombin-cleaved form of osteopontin well correlated with various inflammatory disease activities in not only rodents, but also humans. We previously demonstrated that the blocking of the interaction of a cryptic epitope within osteopontin, which is exposed by thrombin cleavage, with its integrins by s...

journal_title：International immunopharmacology

authors： Yamamoto N,Nakashima T,Torikai M,Naruse T,Morimoto J,Kon S,Sakai F,Uede T

更新日期：2007-11-01 00:00:00

abstract：:Virulizin, a novel biological response modifier, has demonstrated broad antitumor efficacy in a variety of human tumor xenograft models including melanoma, pancreatic cancer, breast cancer, ovarian cancer and prostate cancer. Previous studies have demonstrated a significant role of macrophages and NK cells in the anti...

journal_title：International immunopharmacology

authors： Li H,Cao MY,Lee Y,Benatar T,Lee V,Feng N,Gu X,Liu P,Jin H,Wang M,Der S,Lightfoot J,Wright JA,Young AH

更新日期：2007-10-01 00:00:00

abstract：:Royal jelly (RJ), especially its protein components, has been shown to possess immunomodulatory activity. However, almost nothing is known about the influence of RJ fatty acids on the immune system. In this work we studied the effect of 10-hydroxy-2-decanoic acid (10-HDA) and 3,10-dihydroxy-decanoic acid (3,10-DDA), i...

journal_title：International immunopharmacology

authors： Vucevic D,Melliou E,Vasilijic S,Gasic S,Ivanovski P,Chinou I,Colic M

更新日期：2007-09-01 00:00:00

abstract：:In sequential studies, we compared immune reconstitution following high-dose chemotherapy (HDT) and stem cell transplantation (SCT) using intact mobilized peripheral blood stem cell (PSC) in intermediate grade non-Hodgkin's lymphoma (NHL) patients and CD34(+), lineage-negative (Lin(-)), Thy-1(lo) (CD34(+)Lin(-)Thy-1(l...

journal_title：International immunopharmacology

authors： Singh RK,Varney ML,Leutzinger C,Vose JM,Bierman PJ,Buyukberber S,Ino K,Loh K,Nichols C,Inwards D,Rifkin R,Talmadge JE

更新日期：2007-08-01 00:00:00

abstract：:Water-soluble acidic polysaccharides from the cell walls of Ulva rigida are mainly composed of disaccharides that contain glucuronic acid and sulphated rhamnose. The structure of disaccharides resembles that of glycosaminoglycans (GAGs) as they both contain glucuronic acid and sulphated sugars. Glycosaminoglycans occu...

journal_title：International immunopharmacology

authors： Leiro JM,Castro R,Arranz JA,Lamas J

更新日期：2007-07-01 00:00:00

abstract：:We previously reported that abnormally down-regulated protein kinase C (PKC) activity is responsible for the impaired cellular function of natural killer cells and polymorphonuclear cells (PMNs), and the giant granule formation in fibroblasts in the beige mouse, an animal model of Chediak-Higashi syndrome. Here, we ex...

journal_title：International immunopharmacology

authors： Morimoto M,Tanabe F,Kasai H,Ito M

更新日期：2007-07-01 00:00:00

abstract：:Although it has been shown that functions of immunoglobulin G (IgG) antibodies (Abs) that depend on binding to certain Fc gamma receptors (Fc gamma R) can be influenced by Fc glycan fucosylation, quantitative in vivo analyses comparing the effects of different levels of fucose are still lacking. We used a simple mouse...

journal_title：International immunopharmacology

authors： Scallon B,McCarthy S,Radewonuk J,Cai A,Naso M,Raju TS,Capocasale R

更新日期：2007-06-01 00:00:00

abstract：:Ganoderic acid Me (GA-Me) is a lanostane triterpenoid purified from Ganoderma lucidum mycelia, one of the most widely used herbs for cancer treatment and prevention in east Asia. In the present study, it was demonstrated that GA-Me could inhibit both tumor growth and lung metastasis of Lewis lung carcinoma in C57BL/6 ...

journal_title：International immunopharmacology

authors： Wang G,Zhao J,Liu J,Huang Y,Zhong JJ,Tang W

更新日期：2007-06-01 00:00:00

abstract：:Plants constitute an important source of compounds which can induce apoptosis in a variety of cells. Previously, we reported the isolation of a trypsin inhibitor from Peltophorum dubium seeds (PDTI). This inhibitor, as well as soybean trypsin inhibitor (SBTI), both belonging to the Kunitz family, have lectin-like prop...

journal_title：International immunopharmacology

authors： Troncoso MF,Biron VA,Longhi SA,Retegui LA,Wolfenstein-Todel C

更新日期：2007-05-01 00:00:00

abstract：:The aim of the present study is to probe the anti-inflammatory potential of the plant Boswellia serrata by studying the effect of the crude extract and the pure compound isolated from it on key inflammatory mediators like TNFalpha, IL-1beta, and NO thus enabling the understanding of the key signaling events involved. ...

journal_title：International immunopharmacology

authors： Gayathri B,Manjula N,Vinaykumar KS,Lakshmi BS,Balakrishnan A

更新日期：2007-04-01 00:00:00

abstract：:Increasing evidence is now available showing that CD1-restricted T cell responses against non-peptide mycobacterial antigens could play a role in the immune resistance against tuberculosis. BCG, widely used in anti-tubercular vaccination, shares various constituents with Mycobacterium tuberculosis, but does not provid...

journal_title：International immunopharmacology

authors： Prete SP,Giuliani A,D'Atri S,Graziani G,Balduzzi A,Oggioni MR,Iona E,Girolomoni G,Bonmassar L,Romani L,Franzese O

更新日期：2007-03-01 00:00:00

abstract：:Selective inhibitors of cyclooxygenase-2 (COX-2) enzyme activity have shown chemopreventive activity in carcinogen-induced and transgenic rodent tumor models and clinically for colon cancer. However, the mechanism(s) by which COX-2 inhibitors reduce carcinogenesis remains controversial. We report herein that administr...

journal_title：International immunopharmacology

authors： Talmadge JE,Hood KC,Zobel LC,Shafer LR,Coles M,Toth B

更新日期：2007-02-01 00:00:00

abstract：:Upon activation, microglia release proinflammatory mediators that play important roles in eliciting neuroinflammatory responses associated with neurodegenerative diseases. The anti-inflammatory properties of eicosapentaenoic acid (EPA) have been known, however, the effects responsible for lipopolysaccharide (LPS)-indu...

journal_title：International immunopharmacology

authors： Moon DO,Kim KC,Jin CY,Han MH,Park C,Lee KJ,Park YM,Choi YH,Kim GY

更新日期：2007-02-01 00:00:00

abstract：:During the evolution of neoplastic diseases, dendritic cell (DC) functions are usually attenuated, and this presents a problem to DC-based immunotherapies against cancer. Here, we investigated the effects of angelan, an acidic polysaccharide isolated from Angelica gigas Nakai, on DC maturation. Angelan efficiently inc...

journal_title：International immunopharmacology

authors： Kim JY,Yoon YD,Ahn JM,Kang JS,Park SK,Lee K,Song KB,Kim HM,Han SB

更新日期：2007-01-01 00:00:00

abstract：:Salicylic acid (aspirin) is a widely used pharmacological agent with immunodmodulatory properties. Dendritic cells are key regulators of the immune response, and are capable of inducing hyporesponsiveness and regulatory activity in CD4+ T-cells. We have demonstrated that aspirin-treated dendritic cells are effective a...

journal_title：International immunopharmacology

authors： Buckland M,Jago C,Fazekesova H,George A,Lechler R,Lombardi G

更新日期：2006-12-20 00:00:00

abstract：:The key goal in clinical transplantation is the induction of donor-specific transplantation tolerance to minimise the morbidity and mortality associated with long-term immunosuppression. Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor FoxP3 play a crucial role in the ...

journal_title：International immunopharmacology

authors： Jiang S,Golshayan D,Tsang J,Lombardi G,Lechler RI

更新日期：2006-12-20 00:00:00

abstract：UNLABELLED:A prospective study was performed to evaluate low dose Anti-Thymocyte Globulin (ATG) and Rituximab along with high dose Sirolimus as induction agents for reducing the incidence of acute rejection in renal transplantation. 66 patients who were to undergo live renal transplantation were divided into the low ri...

journal_title：International immunopharmacology

authors： Ravichandran P,Natrajan T,Jaganathan R

更新日期：2006-12-20 00:00:00

abstract：:Bromelain is a natural mixture of proteolytic enzymes derived from pineapple stem that has been shown to have anti-inflammatory activity when administered orally. Although most proteins given orally without adjuvant (e.g., food) result in tolerance, we previously reported that long-term oral exposure to bromelain stim...

journal_title：International immunopharmacology

authors： Hale LP,Fitzhugh DJ,Staats HF

更新日期：2006-12-20 00:00:00

abstract：:Bee venom (BV) has been known to inhibit proliferation and induce apoptosis in cancer cells. However, the molecular mechanisms involved in BV-induced apoptosis are still uncharacterized in human leukemic cells. In the present study, we report that BV induces apoptosis in leukemic U937 cells through downregulation of E...

journal_title：International immunopharmacology

authors： Moon DO,Park SY,Heo MS,Kim KC,Park C,Ko WS,Choi YH,Kim GY

更新日期：2006-12-05 00:00:00

abstract：:Vaccination against nicotine to elicit the production of nicotine-specific antibodies is a potential treatment for tobacco addiction which reduces nicotine distribution from serum to brain. Vaccination of pregnant rats also reduces the distribution of maternally-administered nicotine to the fetal brain. Whether this i...

journal_title：International immunopharmacology

authors： Keyler DE,Lesage MG,Dufek MB,Pentel PR

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate the effects of intra-articular botulinum toxin. METHODS:Osteoarthritis was induced in both knees of 20 rabbits by transecting the anterior cruciate ligament under intramuscular anesthesia with ketamine and xylazine. Botulinum toxin, at a dose of 2.5 microg/ml (0.6 ml) and physi...

journal_title：International immunopharmacology

authors： Namazi H

更新日期：2006-11-01 00:00:00

abstract：:Histamine can modulate the balance between T helper lymphocytes 1 and 2 (Th1 and Th2), and there is evidence that allergic reactions can be associated with excessive histamine production causing shifts toward Th2 responses. As signal transduction in Th-cells is specifically correlated to signal transducer and activato...

journal_title：International immunopharmacology

authors： Horr B,Borck H,Thurmond R,Grösch S,Diel F

更新日期：2006-10-01 00:00:00

abstract：:Opioid abuse has been shown to exacerbate the immunosuppressive effects and pathogenesis of HIV infection. The mu opioid receptor (MOR) is present on immune cells, such as macrophages, and mediates the direct immunomodulatory effects of opioids. Through its surface glycoprotein, gp120, HIV-1 binds to surface receptors...

journal_title：International immunopharmacology

authors： Beltran JA,Pallur A,Chang SL

更新日期：2006-09-01 00:00:00

abstract：:Analogous to reported immunomodulatory effects of probiotics, this study was performed to analyse the immunomodulatory properties of prebiotic oligosaccharides that share chemical characteristics with human milk oligosaccharides. A mixture containing galacto- and fructo-oligosaccharides (GOS/FOS; ratio 9:1) was tested...

journal_title：International immunopharmacology

authors： Vos AP,Haarman M,Buco A,Govers M,Knol J,Garssen J,Stahl B,Boehm G,M'Rabet L

更新日期：2006-08-01 00:00:00

abstract：:Hericium erinaceum is a medicinal and edible mushroom with anti-microbial and anti-cancer activities. To evaluate the immunoregulatory functions of H. erinaceum, we prepared water extract from H. erinaceum (WEHE) and investigated its ability to activate macrophages and to induce nitric oxide (NO) production in macroph...

journal_title：International immunopharmacology

authors： Son CG,Shin JW,Cho JH,Cho CK,Yun CH,Chung W,Han SH

更新日期：2006-08-01 00:00:00

abstract：:The medical lead, so-called Cumaside, was created on the basis of triterpene oligoglycosides from the Far-Eastern edible sea cucumber (holothurian) Cucumaria japonica and its immunomodulatory properties were studied. The haemolytic activity of Cumaside was significantly reduced in comparison with original glycosides d...

journal_title：International immunopharmacology

authors： Aminin DL,Pinegin BV,Pichugina LV,Zaporozhets TS,Agafonova IG,Boguslavski VM,Silchenko AS,Avilov SA,Stonik VA

更新日期：2006-07-01 00:00:00

abstract：:Astragalus mongholicus polysaccharides(ASP) isolated from one of the Chinese herbs-A. mongholicus which are known to have a variety of immunomodulatory activity. However, little is known about their immunomodulatory effects on murine bone marrow (BM)-derived dendritic cells (DC). DC are professional antigen presenting...

journal_title：International immunopharmacology

authors： Shao P,Zhao LH,Zhi-Chen,Pan JP

更新日期：2006-07-01 00:00:00

abstract：:Cathepsin K (Cat K) is the major cysteine protease expressed in osteoclast and is thought to play a key role in matrix degradation during bone resorption. It is shown that the intracellular maturation of Cat K was prevented by the cAMP antagonist, Rp-cAMP, and the protein kinase A (PKA) inhibitors of KT5720 and H89. I...

journal_title：International immunopharmacology

authors： Park YG,Kim YH,Kang SK,Kim CH

更新日期：2006-06-01 00:00:00

abstract：:The neuropharmacological properties of cocaine are known to be associated with the activation of sigma-1 receptors. Cocaine also has been shown to alter both cytokine production and HIV-1 expression in mononuclear phagocytes, including microglial cells. This study tested the hypothesis that sigma-1 receptors and trans...

journal_title：International immunopharmacology

authors： Gekker G,Hu S,Sheng WS,Rock RB,Lokensgard JR,Peterson PK

更新日期：2006-06-01 00:00:00

abstract：:The purpose of this study was to prepare a tetravalent anti-human CD22 recombinant antibody with improved antitumor activity and a half life longer than that of its divalent counterpart. We compared the ability of tetravalent vs. divalent antibody to associate/dissociate to/from CD22-positive Daudi cells, to interact ...

journal_title：International immunopharmacology

authors： Liu XY,Pop LM,Roopenian DC,Ghetie V,Vitetta ES,Smallshaw JE

更新日期：2006-05-01 00:00:00